If Daenerys Targaryen, Mother of Dragons, were to have a child with Jon Snow, would their child be born with birth defects because the two are related?
When inquiring as to whether such irregularities occur with every intrafamilial marriage, the answer is that the risks are much greater than in non-kinship marriages. For example, regular marriages carry a 3% risk of offspring being born with an abnormality. However, this number is doubled for marriages of people who are related to one another, meaning a risk level of 6%.
So, going back to the question of whether unrelated married couples are also at risk of giving birth to a child with a genetic disorder – the answer is yes, should the mother or father already carry those defective genes. Nevertheless, prospective parents can undergo genetic screening to identify the presence of such genes prior to conception.
Through next generation sequencing (NGS), we can currently identify and prevent against the occurrence of genetic disorders with family planning in consultation with genetic specialists who can identify the risk of genetically transferring disorders. This method of screening allows for the rapid and accurate screening of high sensitivity genetic mutations in DNA to provide a risk analysis for any offspring. It also enables couples to make plans to ensure the health and safety of their child, whether that couple is related or not.
The First Class Honors M.D. ,Faculty of Medicine Ramathibodi Hospital, Mahidol University. Faculty of Medicine Ramathibodi Hospital, Mahidol University , 2000